The 15-year-old son of Madonna and Guy Ritchie, who had 138 000 followers on the photo-sharing website, opted to delete his account amid a reported feud with his mother.
While it was previously claimed that Rocco had blocked Madonna from seeing his posts on the website, he has now decided to remove his page altogether, according to RadarOnline.
A source previously said: "It's not a great sign that Rocco is blocking his mum on social media, especially after all the reports that she was embarrassing him with her posts about him.
"It's even more of a blow because he allows Jacqui Ainsley, his stepmother and Guy to still follow him and he follows them back. Hopefully this is just a teenage teething problem."
The news that Rocco has deleted his account comes amid claims Guy hired a lawyer to fight for custody of his son.
Rocco, is keen to live in London full-time with his father and defied a recent court order to return to New York to be with his mother, and the director is doing his best to support the teenager's position.
According to TMZ, Rocco - and his father - feels he has a more "stable and loving" home life with Guy, his wife Jacqui and their three children, Rafael, four, Rivka, three, and Levi, 18 months.
The teenager thinks his Like a Virgin singer mother is "too controlling" and doesn't pay him any real attention.
Because of Rocco's strong views, Guy has now hired a lawyer and is preparing for a legal battle to keep custody of his son, who left Madonna's tour a month ago and refused to return to her for Christmas.
A New York judge has ordered Rocco back to the US for a hearing next month.